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Sex differences in rapid auditory processing deficits in ectopic BXSB/MpJ mice
Ann M Peiffer1, Glenn D Rosen, R Holly Fitch
1Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA.
Neuroreport
|December 19, 2002
Summary
Male mice with focal cortical malformations show auditory processing deficits, particularly at short intervals. These deficits were not observed in female mice, suggesting sex differences in the effects of these brain abnormalities.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Auditory Neuroscience
Background:
- Focal neocortical malformations, such as ectopias and microgyria, are linked to auditory processing deficits in male rodents.
- Previous research primarily focused on male subjects, leaving potential sex differences unexplored.
Purpose of the Study:
- To investigate sex differences in auditory processing deficits associated with focal cortical malformations.
- To determine if male BXSB/MpJ mice with ectopias exhibit rapid auditory processing impairments.
Main Methods:
- Utilized BXSB/MpJ mouse model with naturally occurring focal cortical malformations.
- Assessed auditory processing using a two-tone oddball stimulus at varying inter-stimulus intervals.
- Compared auditory detection performance between ectopic and non-ectopic male and female littermates.
Main Results:
- Ectopic male mice demonstrated impaired detection of the two-tone oddball stimulus at short inter-stimulus intervals compared to non-ectopic males.
- No significant auditory processing deficit was observed in ectopic female mice compared to their non-ectopic counterparts.
- Findings support an association between focal cortical malformations and auditory processing deficits in males.
Conclusions:
- Results confirm a link between focal cortical malformations and impaired auditory processing in males.
- The study highlights significant sex differences in the behavioral outcomes of focal cortical malformations.
- Further research is warranted to elucidate the mechanisms underlying these sex-specific effects.