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Immunosuppressive activity of concanavalin A
International Archives of Allergy and Applied Immunology
|January 1, 1976
Summary
Daily doses of concanavalin A (Con A) effectively inhibited and relieved arthritis in rats. Pre-incubation with ovalbumin neutralized Con A
Area of Science:
- Immunology
- Pharmacology
- Rheumatology
Background:
- Adjuvant-induced arthritis is a common model for rheumatoid arthritis.
- Concanavalin A (Con A) is a plant lectin with known immunomodulatory effects.
Purpose of the Study:
- To investigate the therapeutic potential of Con A in a rat model of arthritis.
- To determine the effect of Con A on both the development and established stages of adjuvant-induced arthritis.
Main Methods:
- Rats were administered daily intraperitoneal doses of Con A.
- Arthritis was induced using the standard adjuvant method.
- Established arthritis was treated with Con A.
- Con A's inhibitory effect was tested after pre-incubation with ovalbumin.
Main Results:
- Con A demonstrated a dose-related inhibition of adjuvant-induced arthritis.
- Three doses of Con A significantly relieved established arthritis symptoms.
- Pre-incubation with ovalbumin neutralized the arthritis-inhibitory effect of Con A.
Conclusions:
- Concanavalin A exhibits significant therapeutic potential for treating arthritis.
- Ovalbumin can block the arthritis-inhibitory action of Con A, suggesting an immune-mediated mechanism.