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Exercise training does not reduce hyperlipidemia in pigs fed a high-fat diet
Tom R Thomas1, Jonathan Pellechia, R Scott Rector
1Department of Nutritional Sciences, Veterinary Biomedical Sciences, University of Missouri-Columbia, Columbia, MO, USA.
Metabolism: Clinical and Experimental
|December 19, 2002
Summary
An atherogenic diet significantly impacts pig lipoproteins and lipoprotein lipase activity, with females showing a more exaggerated response than males. Exercise training did not alter these diet-induced effects in this study.
Area of Science:
- Cardiovascular Science
- Nutritional Science
- Animal Models
Background:
- Pigs are a common model for studying human atherosclerosis and lipoprotein metabolism.
- Limited research exists on the complete lipoprotein profile and related enzymes in swine fed an atherogenic diet.
Purpose of the Study:
- To investigate the effects of an atherogenic diet on lipoprotein profiles and lipoprotein lipase (LPL) activity in miniature swine.
- To determine if exercise training moderates the impact of an atherogenic diet on lipoproteins and LPL activity.
Main Methods:
- Miniature swine (male and female) were fed either a low-fat diet or an atherogenic diet for 30 days.
- Following the dietary period, pigs were assigned to sedentary or exercise-trained groups for 16-20 weeks.
- A 4-way ANOVA with repeated measures was used to analyze lipoprotein variables and LPL activity.
Main Results:
- The atherogenic diet significantly increased cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and LPL activity in both genders.
- Female swine exhibited a more pronounced response to the atherogenic diet compared to males for several lipoprotein variables.
- Exercise training did not result in significant group differences or interactions on any measured lipoprotein variable.
Conclusions:
- An atherogenic diet has a greater impact on the lipoproteins of female miniature swine than males.
- Under the study's conditions, exercise training does not mitigate the effects of an atherogenic diet on swine lipoproteins.