[Innovative treatment in oncology]

Area of Science:

• Oncology
• Molecular Biology
• Pharmacology

Background:

• Advances in understanding cell transformation and tumor progression.
• Identification of novel therapeutic targets for cancer treatment.

Purpose of the Study:

• To highlight the importance of molecular mechanisms in identifying new anticancer therapeutic targets.
• To emphasize the need for surrogate markers in patient selection and monitoring of molecular-targeting compounds.

Main Methods:

• Review of current knowledge on molecular mechanisms in cancer.
• Discussion of molecular-targeting compounds (e.g., anti-angiogenesis, tyrosine kinase inhibitors).

Main Results:

• Improved knowledge of molecular mechanisms facilitates the discovery of new therapeutic targets.
• Development of molecular-targeting compounds offers selective interference with tumor growth.

Conclusions:

• Rationale patient selection and pharmacodynamic monitoring require accessible surrogate markers.
• Biomarkers in tumor tissue or blood are essential for personalized cancer therapy.