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[Chemokines and tumors].

Antonio Pellegrino1, Angelo Vacca, Claudio Scavelli

  • 1Dipartimento di Scienze Biomediche e Oncologia Umana, Università, Bari. antoniopellegrino@hotmail.com

Recenti Progressi in Medicina
|December 20, 2002
PubMed
Summary

Chemokines regulate cell migration and are involved in tumor progression. Some chemokines inhibit tumor growth, while others promote it by activating specific receptors on cancer cells, leading to invasion and metastasis.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Context:

  • Chemokines are crucial cytokines that control cell movement, impacting inflammation, immune responses, and leukocyte homing.
  • They play significant roles in tumor-associated angiogenesis and cancer progression.
  • Chemokines are classified into four main subfamilies (CXC, CC, C, CX3C) based on their structure, each interacting with specific cell surface receptors.

Purpose:

  • To review the dual role of chemokines in cancer, highlighting their involvement in both tumor suppression and promotion.
  • To discuss the expression of chemokine receptors on neoplastic cells and their functional consequences.
  • To present findings on CXCR3 expression in lymphoproliferative diseases and its link to invasive phenotypes.

Summary:

  • Chemokines, including CXC and CC types, are found in tumor tissues and patient fluids, influencing tumor behavior.
  • While some chemokines inhibit tumor growth by activating immune cells or hindering angiogenesis, others promote it.
  • Tumor cells can express specific chemokine receptors, such as CXCR3 in multiple myeloma and lymphoma, which upon chemokine interaction, can stimulate invasive properties.

Impact:

  • Understanding chemokine roles in cancer provides insights into potential therapeutic targets for modulating immune responses and tumor progression.
  • Identifying specific chemokine-receptor interactions on cancer cells may lead to novel strategies for treating lymphoproliferative diseases.
  • This research underscores the complex involvement of chemokines in cancer biology, offering avenues for diagnostic and therapeutic advancements.

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