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Updated: Jul 2, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Hydrogen bond-stabilized helix formation of a m-phenylene ethynylene oligomer
Jennifer M Cary1, Jeffrey S Moore
1Department of Chemistry and Materials Science, The University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Abstract:
[reaction: see text] Incorporation of a single hydrogen bonded beta-turn mimic in the backbone of a m-phenylene ethynylene oligomer is shown to affect the thermodynamic properties of the folding reaction. Oligomers 1 and 2 both undergo solvophobic helix formation, but hydrogen bonded oligomer 1 was found to form a more stable helix with a higher tolerance to solvent denaturation than isomeric, non-hydrogen bonded oligomer 2.
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