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Studies directed toward asymmetric synthesis of cardioactive steroids via anionic polycyclization
Zhixiang Yang1, Dean Shannon, Vouy-Linh Truong
1Laboratoire de synthèse organique, Institut de pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada.
Organic Letters
|December 20, 2002
Abstract:
[reaction: see text] The use of anionic polycyclization (AP) in constructing the steroidal backbone of cardenolides was investigated. The reaction of 2-carbomethoxy-2-cyclohexenone I with the enolate of Nazarov reagent II gave, after decarboxylation and aldol condensation, steroid III with control of stereochemistry.