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Analgesic activity of Enhydra fluctuans
M T Rahman1, N Begum, M Alimuzzaman
1Pharmacology Research Laboratory, Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh. mtrahmanbd@yahoo.com
Fitoterapia
|December 20, 2002
Summary
The methanol extract of Enhydra fluctuans demonstrated significant pain-relieving properties in animal studies. This natural compound shows potential as an analgesic agent.
Area of Science:
- Pharmacology
- Ethnobotany
- Natural Product Chemistry
Background:
- Enhydra fluctuans is a plant used in traditional medicine.
- Pain management remains a significant global health challenge.
- Exploring natural products for therapeutic agents is crucial.
Purpose of the Study:
- To evaluate the analgesic activity of Enhydra fluctuans methanol extract.
- To investigate the plant's potential in pain relief.
Main Methods:
- Oral administration of Enhydra fluctuans methanol extract at 250 and 500 mg/kg doses.
- Assessment of analgesic effects using the acetic acid induced writhing test.
- Evaluation of pain response via the tail-flick method.
Main Results:
- The Enhydra fluctuans extract exhibited dose-dependent analgesic activity.
- Significant reduction in writhing episodes was observed.
- Increased tail-flick latency indicated pain relief.
Conclusions:
- Enhydra fluctuans possesses notable analgesic properties.
- The methanol extract is a promising candidate for further development as a natural pain reliever.
- Supports the traditional use of Enhydra fluctuans for pain management.