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Related Experiment Videos

Depression treatment: a lifelong commitment?

Martin B Keller1, Ernst R Berndt

  • 1Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA. sheri_harrison@brown.edu

Psychopharmacology Bulletin
|December 20, 2002
PubMed
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Depression undertreatment is common, leading to significant disability and economic burden. Effective treatment aims for full symptom resolution and long-term recovery, requiring further research into maintenance pharmacotherapy and psychotherapy.

Area of Science:

  • Psychiatry
  • Clinical Psychology

Background:

  • Depression causes significant disability, morbidity, and mortality, often with relapse or recurrence.
  • A substantial number of patients with depressive disorders remain undertreated, imposing economic burdens.
  • Undertreatment stems from patient, provider, and healthcare system factors.

Purpose of the Study:

  • To highlight the critical need for appropriate treatment targeting to prevent depressive relapse and recurrence.
  • To emphasize that optimal outcomes should focus on full symptom resolution (remission) and long-term recovery, not just short-term symptom improvement.
  • To identify the urgent need for more data on the outcomes and duration of maintenance pharmacotherapy for recurrent depression.

Main Methods:

  • Review of existing evidence on depression undertreatment and its consequences.

Related Experiment Videos

  • Discussion of factors contributing to undertreatment.
  • Reference to a recent 12-week randomized controlled study on psychotherapy, including its ongoing maintenance phase.

    • Main Results:

    • The majority of patients with depressive disorders are undertreated.
    • Undertreatment leads to considerable societal economic burden.
    • Evidence suggests psychotherapy benefits, with ongoing research into maintenance treatment.

    Conclusions:

    • Appropriate treatment is vital to break the cycle of depression relapse/recurrence.
    • Long-term, indefinite treatment may be necessary for patients with recurrent depressive episodes.
    • Well-designed studies are urgently needed to guide maintenance pharmacotherapy and psychotherapy duration.