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Inflammation

Inflammation

Inflammatory Response I: Vascular and Cellular

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Inflammation: Introduction

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jun 24, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Inflammation and cancer.

Lisa M Coussens¹, Zena Werb

¹Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA. coussens@cc.ucsf.edu

|December 20, 2002

Summary

This summary is machine-generated.

Inflammation plays a key role in cancer progression by influencing the tumor microenvironment and promoting cancer cell survival and spread. Targeting inflammation offers new therapeutic strategies for cancer development.

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Area of Science:

Oncology
Immunology
Cancer Biology

Background:

Inflammation is increasingly recognized as a critical factor in tumor progression.
Many cancers originate from sites of chronic irritation and inflammation.
The tumor microenvironment, driven by inflammatory cells, significantly impacts cancer development.

Purpose of the Study:

To explore the role of inflammation in tumor progression.
To understand how inflammatory cells and signaling molecules contribute to cancer.
To highlight the potential of anti-inflammatory therapies in cancer treatment.

Main Methods:

Review of recent data on inflammation and cancer.
Analysis of the tumor microenvironment's role.
Examination of molecular mechanisms involving innate immune system signaling.

Main Results:

Inflammation is integral to tumor progression, fostering proliferation, survival, and migration.
Tumor cells utilize innate immune signaling molecules for invasion and metastasis.
The tumor microenvironment is orchestrated by inflammatory cells.

Conclusions:

Inflammation is a key driver of cancer development.
Understanding these mechanisms opens avenues for anti-inflammatory cancer therapies.
Targeting inflammation presents a promising therapeutic strategy for cancer.