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[Allergic fungal sinusitis]
Yoshinori Matsuwaki1, Kiyoshi Yanagi, Tsuneya Nakajima
1Department of Otorhinolaryngology, Tokyo Dental College, Ichikawa General Hospital, Ihcikawa.
Nihon Jibiinkoka Gakkai Kaiho
|December 21, 2002
Summary
Allergic fungal sinusitis (AFS) is a rare condition in Japan, affecting 3.9% of patients undergoing endoscopic sinus surgery. Immunoglobulin E (IgE) antibody-mediated allergy may play a role in its development.
Area of Science:
- Otolaryngology
- Allergy Immunology
Context:
- Allergic fungal sinusitis (AFS) is a refractory condition with high recurrence rates.
- AFS incidence in Europe and the US is 4%-7% among chronic sinusitis patients undergoing endoscopic sinus surgery (ESS).
- AFS is notably rare in Japan, with only 5 reported cases prior to this study.
Purpose:
- To prospectively investigate the incidence, pathogenesis, and diagnosis of AFS in Japan.
- To compare AFS incidence in Japan with that reported in Europe and the United States.
- To explore the potential role of IgE-mediated allergy in AFS pathogenesis.
Summary:
- This study prospectively evaluated 102 patients with chronic sinusitis undergoing ESS in Japan.
- Four cases (3.9%) were diagnosed with AFS using the Bent and Kuhn criteria, a rate comparable to Western countries.
- Allergen provocation tests in two patients showed immediate positive reactions, suggesting IgE antibody-mediated type I allergy involvement.
Impact:
- This research establishes a more accurate incidence rate for AFS in Japan.
- It provides insights into the diagnostic and pathogenic mechanisms of AFS in a Japanese population.
- Findings suggest potential therapeutic targets related to IgE-mediated allergic responses.