[Progress in developing anti-Alzheimer drugs]

According to the amyloid hypothesis, accumulation of beta amyloid in the brain seems to be the primary influence driving Alzheimer's disease pathogenesis. From the studies of A beta production, aggregation, degradation and clearance, several strategies for preventing or delaying the disease onset and progression have been postulated. These are beta-secretase inhibitors, gamma-secretase inhibitors, A beta degrading enzymes, anti-cholesterol drugs, non-steroidal anti-inflammatory drugs, beta-sheet breakers, chelating agents, SAP competitors, beta-amyloid vaccination, agents for trapping peripheral A beta, and so on. Here I review recent progress in developing anti-Alzheimer drugs.