Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urinary androstanediol and testosterone in adults.

Y Doberne, M I New

    The Journal of Clinical Endocrinology and Metabolism
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Guest Editor's Foreword.

    Pediatric annals·2014
    Same author

    Idiopathic precocious puberty in girls: Psychosexual development.

    Journal of youth and adolescence·2013
    Same author

    Erroneous prenatal diagnosis of congenital adrenal hyperplasia owing to a duplication of the CYP21A2 gene.

    Journal of perinatology : official journal of the California Perinatal Association·2012
    Same author

    Pregnancy outcomes in women with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    Journal of pediatric endocrinology & metabolism : JPEM·2005
    Same author

    Update on the prenatal diagnosis and treatment of congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.

    Journal of pediatric endocrinology & metabolism : JPEM·2005
    Same author

    The natural history and genotype-phenotype nonconcordance of HLA identical siblings with the same mutations of the 21-hydroxylase gene.

    Journal of pediatric endocrinology & metabolism : JPEM·2005

    Urinary androstanediol and testosterone excretion levels were measured in healthy adults. In women, androstanediol levels were significantly higher than testosterone, challenging its use as a sole indicator of testosterone 5alpha-reduction.

    Area of Science:

    • Endocrinology
    • Metabolism
    • Urology

    Background:

    • Androstanediol and testosterone are key androgens.
    • Urinary excretion levels can reflect endogenous androgen production and metabolism.
    • The 5alpha-reduction of testosterone is a critical metabolic pathway.

    Purpose of the Study:

    • To quantify and compare daily urinary excretion of androstanediol and testosterone in healthy adults.
    • To investigate the relationship between urinary androstanediol and testosterone levels.
    • To evaluate the hypothesis that urinary androstanediol reflects 5alpha-reduction in androgen target tissues.

    Main Methods:

    • Utilized a sensitive radioligand assay for precise quantification.
    • Collected and analyzed daily urine samples from healthy adult men and women.

    Related Experiment Videos

  • Performed statistical analysis to compare excretion levels between sexes and hormones.

    • Main Results:

    • In healthy men, mean urinary androstanediol (79 mug/day) was comparable to testosterone (84 mug/day).
    • In healthy women, mean urinary androstanediol (12 mug/day) was significantly higher than testosterone (4.2 mug/day).
    • In all females studied, urinary androstanediol consistently exceeded urinary testosterone.

    Conclusions:

    • Urinary androstanediol excretion is not significantly different from testosterone in men.
    • Urinary androstanediol levels are significantly higher than testosterone in women.
    • These findings do not support the hypothesis that urinary androstanediol directly measures 5alpha-reduction of testosterone in androgen target tissues.