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Human serum melatonin changes during the menstrual cycle.

L Wetterberg, J Arendt, L Paunier

    The Journal of Clinical Endocrinology and Metabolism
    |January 1, 1976
    PubMed
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    Serum melatonin levels in women peak during early morning menstruation and reach their lowest point during the menstrual cycle. This study investigated the relationship between melatonin and the menstrual cycle in healthy women.

    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Chronobiology

    Background:

    • Melatonin is a key hormone regulating sleep-wake cycles and exhibits diurnal variations.
    • The menstrual cycle involves complex hormonal fluctuations that can influence various physiological processes.
    • Understanding the interplay between melatonin and the menstrual cycle is crucial for reproductive health research.

    Purpose of the Study:

    • To investigate the diurnal pattern of serum melatonin concentration in relation to the menstrual cycle phases.
    • To determine if melatonin levels correlate with specific stages of the menstrual cycle in healthy women.

    Main Methods:

    • Serum samples were collected in the early morning from five healthy women.
    • Melatonin concentrations were measured during different phases of the menstrual cycle.

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    Main Results:

    • Serum melatonin concentration was found to be elevated during the early morning hours coinciding with menstrual bleeding.
    • Melatonin levels reached their nadir (lowest point) during the mid-menstrual cycle phase.

    Conclusions:

    • Early morning serum melatonin concentrations exhibit a distinct pattern throughout the menstrual cycle.
    • Melatonin levels appear to be associated with menstrual bleeding and mid-cycle phases in women.