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Related Experiment Video

Updated: May 12, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

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An improved technique for nasal inhalation challenge tests.

J A McLean, A A Ciarkowski, W R Solomon

The Journal of Allergy and Clinical Immunology

|February 1, 1976

Summary

This study introduces an improved nasal inhalation challenge test using a precise delivery system and a new mask. These advancements reduce variability in nasal airway resistance measurements for better diagnostic accuracy.

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

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Published on: March 3, 2023

Area of Science:

Allergy and Immunology
Respiratory Medicine
Medical Device Technology

Background:

Nasal inhalation challenge tests are crucial for diagnosing allergic and non-allergic rhinitis.
Existing methods for delivering nasal aerosols can lead to significant variability in patient response.
Accurate measurement of nasal airway resistance (NAR) is essential for objective assessment.

Purpose of the Study:

To describe an improved technique for nasal inhalation challenge testing.
To enhance the precision and reduce variability in nasal aerosol delivery and NAR measurements.
To introduce a novel face mask designed for improved comfort and measurement accuracy.

Main Methods:

Utilized a Maxi-Myst air compressor with an electronically timed solenoid for precise aerosol delivery control.
Employed a DeVilbiss atomizer (No. 251) calibrated for specific output (0.1 ± 0.01 gm/spray) at a flow rate of 11.5 L/min.
Tested different volumes (0.1 ml vs. 0.2 ml) of buffered saline for nasal aerosol challenge and introduced a new mask design.

Main Results:

A 0.1 ml nasal aerosol challenge per nostril demonstrated less variability in nasal airway resistance response compared to 0.2 ml.
The smaller volume (0.1 ml) was sufficient for multiple (6) consecutive saline challenges.
The new face mask design resulted in lower baseline NAR values and reduced measurement variability.

Conclusions:

The described improved technique enhances the reliability of nasal inhalation challenge tests.
Precise control over aerosol delivery and a new mask design significantly reduce variability in NAR measurements.
This optimized method offers a more accurate and reproducible approach for evaluating nasal responses to exogenous substances.