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Published on: February 14, 2018
Antifungal activity of the echinocandin anidulafungin (VER002, LY-303366) against yeast pathogens: a comparative
María Pilar Arévalo1, Alfonso-Javier Carrillo-Muñoz, Javier Salgado
1Cátedra de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de la Laguna, 38071 La Laguna, Tenerife, Spain. mpareval@ull.es
Abstract:
This study further evaluated the in vitro activity of anidulafungin (VER002, Versicor Inc.) (LY303366) against 460 clinical yeast isolates. MICs of anidulafungin, fluconazole and itraconazole were determined by following the NCCLS M27-A guidelines. Minimum fungicidal concentrations (MFCs) of anidulafungin were determined for 230 isolates of Candida spp. The activity of anidulafungin in vitro was significantly superior (P < 0.05) to those of itraconazole and fluconazole against Candida albicans, Candida tropicalis, Candida glabrata and Candida krusei, but anidulafungin was less active for Candida famata and Candida parapsilosis. The differences were not significant for the other species evaluated.
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