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Related Experiment Videos

Age-related changes in hepatic fine structure: a quantitative analysis.

D L Schmucker

    Journal of Gerontology
    |March 1, 1976
    PubMed
    Summary
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    Aging male rats show significant changes in liver cell structure. Hepatocytes grow larger, with increased organelle volumes, but reduced Golgi membrane surface area, indicating age-related hepatic alterations.

    Area of Science:

    • Hepatology
    • Cell Biology
    • Aging Research

    Background:

    • Liver structure undergoes changes with age.
    • Understanding these changes is crucial for aging research.

    Purpose of the Study:

    • To quantitatively evaluate age-related changes in hepatic fine structure.
    • To compare these changes between virgin and retired breeder male rats.

    Main Methods:

    • Morphometric analysis of centrolobular hepatocytes.
    • Quantitative evaluation of cellular components including nuclei, cytoplasm, organelles, and endoplasmic reticulum.

    Main Results:

    • Hepatocytes increase in size with age (up to 480 days).
    • Smooth-surfaced endoplasmic reticulum (SER) surface area increases with age.

    Related Experiment Videos

  • Virgin rats show greater amounts of both SER and rough-surfaced endoplasmic reticulum.
  • Lysosome volume increases, while Golgi membrane surface area decreases with age.

    • Conclusions:

    • Specific, quantifiable alterations in hepatic fine structure occur during aging.
    • These structural changes vary between different rat breeding statuses.