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[Lipoprotein (a) and ischemic heart disease in patients with hypertensive disease]

V V Britareva, O I Afanas'eva, A B Dobrovol'skiĭ

    Kardiologiia
    |December 21, 2002
    PubMed

    Insights

    Elevated lipoprotein (a) levels are linked to ischemic heart disease (IHD) in hypertensive men. However, this association was not observed in hypertensive women or when comparing hypertensive patients to those with normal blood pressure.

    Area of Science:

    • Cardiovascular Medicine
    • Clinical Biochemistry
    • Hypertension Research

    Background:

    • Lipoprotein (a) [Lp(a)] is an established risk factor for atherosclerotic cardiovascular diseases.
    • Essential hypertension is a major risk factor for ischemic heart disease (IHD).
    • The relationship between Lp(a) levels and IHD in hypertensive patients requires further elucidation.

    Purpose of the Study:

    • To investigate the association between serum lipoprotein (a) levels and the presence of ischemic heart disease (IHD).
    • To compare Lp(a) levels in patients with hypertensive disease versus those with normal blood pressure.
    • To analyze gender-specific differences in the relationship between Lp(a), hypertension, and IHD.

    Main Methods:

    • Cross-sectional study involving 191 patients with essential hypertension and 33 normotensive controls.
    • Measurement of serum lipoprotein (a) concentrations using established biochemical assays.
    • Statistical analysis to compare Lp(a) levels between groups, stratified by gender and IHD status.

    Main Results:

    • Men with hypertension and IHD exhibited significantly higher median Lp(a) levels (19 mg/dl) compared to hypertensive men without IHD (9 mg/dl; p=0.02).
    • No significant difference in median Lp(a) levels was found between hypertensive women with IHD (13 mg/dl) and without IHD (15 mg/dl; p=0.89).
    • Median Lp(a) levels did not significantly differ between the hypertensive group (14 mg/dl) and the normotensive control group (10 mg/dl; p=0.50).

    Conclusions:

    • Elevated lipoprotein (a) levels are significantly associated with ischemic heart disease in men with essential hypertension.
    • This association between Lp(a) and IHD is not evident in hypertensive women.
    • Hypertension itself, independent of IHD, was not associated with significantly different Lp(a) levels compared to normotensive individuals in this cohort.

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