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Updated: Aug 19, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
[C-reactive protein as possible early prognostic marker of restenosis development in coronary artery stents]
Aim:
To study possible link between inflammatory response of the body to stent implantation and development of instent restenosis.
Methods:
C-reactive protein (CRP) was determined in 24 patients subjected to coronary stenting. Coronary angiography was repeated in 7.1-/+0.68 months after initial procedure.
Results:
At repeat angiography positive results of stenting persisted in 18 while restenosis developed in 6 patients. All patients had increased CRP levels on days 2-3 after stenting. Day 2 CRP levels were higher in patients with than without restenosis (28-/+4.22 mg/l and 14.17-/+2.14 mg/l, respectively, p<0.05). CRP levels tended to normalize by day 5.
Conclusion:
Coronary artery stenting in patients with angina pectoris is associated with transitory elevation of CRP level. Day 2 CRP >or=24 mg/l with high degree of probability predicts restenosis in remote period.
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