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Sildenafil use in patients with olanzapine-induced erectile dysfunction
M Atmaca1, M Kuloglu, E Tezcan
1Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey. matmaca_p@yahoo.com
International Journal of Impotence Research
|December 21, 2002
Summary
Sildenafil effectively treats erectile dysfunction (ED) caused by olanzapine, an antipsychotic medication. This study found sildenafil to be well-tolerated and beneficial for patients experiencing this specific side effect.
Area of Science:
- Pharmacology
- Psychiatry
- Urology
Background:
- Antipsychotic medications like olanzapine can cause erectile dysfunction (ED) as a side effect.
- Erectile dysfunction significantly impacts patient quality of life and treatment adherence.
Purpose of the Study:
- To evaluate the efficacy and safety of sildenafil in treating olanzapine-induced erectile dysfunction.
- To assess the impact of sildenafil on patient-reported outcomes for ED.
Main Methods:
- A cohort of 10 patients with olanzapine-induced ED received sildenafil (50 mg, with titration to 100 mg if needed).
- Efficacy was measured using the Clinical Global Impression-Improvement (CGI-I) and International Index of Erectile Dysfunction (IIEF) scales at baseline and weeks 2 and 4.
Main Results:
- Significant improvements were observed in patient-reported outcomes.
- According to CGI-I, 3 patients reported 'very much improved' and 4 reported 'much improved' at week 4.
- Sildenafil was generally well-tolerated with no major adverse events reported.
Conclusions:
- Sildenafil is an effective and well-tolerated treatment option for erectile dysfunction induced by olanzapine.
- Addressing antipsychotic-induced ED with sildenafil may improve patient quality of life and treatment adherence.