Semiparametric modeling of labeled-cell kinetics, with application to isotope labeling of erythrocytes
Related Experiment Video
Updated: Sep 28, 2026

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
Published on: May 22, 2012
Hans-Georg Müller1, Chun-Lung Su, Stephen R Dueker
1Department of Statistics, University of California, One Shields Avenue, Davis, California 95616, USA. mueller@wald.ucdavis.edu
Abstract:
We propose a stochastic model for the kinetics of cells that have been tagged with a chemical label. The proposed model consists of two components: a parametrically specified distribution for the time to incorporation of the label into the cells and a nonparametric survival function reflecting the survival time of the label-cell combination. The target quantity of this modeling approach is the fraction of labeled cells among all cells, viewed as a function of time. Longitudinal measurements of this labeled-cell fraction are available from a recent experiment with folate-labeled red blood cells. The proposed semiparametric model is fitted to these data and some of the implications are explored. The proposed method also includes bootstrap-based inference.
More Related Videos
Related Concept Videos
Mechanistic Models: Compartment Models in Individual and Population Analysis
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...

