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Effect of different curcumin dosages on human gall bladder
Abdul Rasyid1, Abdul Rashid Abdul Rahman, Kamaruddin Jaalam
1School of Medicine, University of North Sumatera, Medan, Indonesia. rasyid_1506@yahoo.com
Asia Pacific Journal of Clinical Nutrition
|December 24, 2002
Summary
A 40 mg dose of curcumin effectively contracts the gallbladder by 50%. This study on curcumin
Area of Science:
- Pharmacology
- Gastroenterology
- Natural Products
Background:
- Curcumin, derived from Curcuma species, exhibits a cholekinetic effect.
- Previous research indicated a 20 mg curcumin dose contracts the gallbladder by 29% within 2 hours.
Purpose of the Study:
- To determine the specific curcumin dosage required for 50% gallbladder contraction.
- To investigate the dose-response relationship between curcumin and gallbladder contraction.
Main Methods:
- Randomized, single-blind, three-phase, crossover study with 12 healthy volunteers.
- Serial ultrasonography to measure gallbladder volume changes.
- Data analyzed using analysis of variance (ANOVA).
Main Results:
- A curcumin dose of 40 mg resulted in a 51.15% decrease in gallbladder volume.
- Doses of 20 mg, 40 mg, and 80 mg induced gallbladder contractions of 34.10%, 51.15%, and 72.25%, respectively (P < 0.01).
- No linear correlation was observed between doubling curcumin dosage and doubling gallbladder contraction.
Conclusions:
- 40 mg of curcumin is the effective dose for achieving 50% gallbladder contraction.
- The dose-response relationship for curcumin-induced gallbladder contraction is not linear.