Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A relative value method for measuring and evaluating cardiac reserve.

Shouzhong Xiao1, Xingming Guo, Xiaobo Sun

  • 1Biomedical Engineering Department, Chongqing University, Chongqing 400044, China. xiaosz@cq.cnuninet.net

Biomedical Engineering Online
|December 24, 2002
PubMed
Summary

New indicators derived from heart sound amplitude, including cardiac contractility change trend (CCCT), can effectively evaluate cardiac function and reserve mobilization. These novel metrics offer insights into cardiac health beyond traditional measures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kilogram-Scale Synthesis of Few-Layer Graphene-Skinned Copper Powders via Pulsed-Pressure Chemical Vapor Deposition.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Site-Specific Carbazole-Bridged Isomeric Guests Enable Organic Solar Cells with 21.10% Efficiency and Reduced Non-Radiative Recombination.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Unveiling a unique microglial phenotype promoting oxidation in the iBRB: insights from single-cell transcriptomics in the NPDR rat model.

Cell & bioscience·2026
Same author

Clinical features, outcome and HLA subtypes in Eastern patients with anti-IgLON5 disease: a multicenter study.

Orphanet journal of rare diseases·2026
Same author

Corrigendum to "Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway" [J. Ethnopharmacol. 322 (2024) 117672].

Journal of ethnopharmacology·2026
Same author

Two-Dimensional Metal-Organic Frameworks as Charge Extraction Media Enabling Binary Organic Solar Cells With 20.70% Efficiency.

Angewandte Chemie (International ed. in English)·2026

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Physiology

Background:

  • Absolute first heart sound (S1) amplitude is limited in evaluating cardiac contractility.
  • Previous studies established a link between S1 amplitude and cardiac contractility.
  • Relative value indicators are needed for accurate cardiac function assessment.

Purpose of the Study:

  • To develop and validate novel indicators for assessing cardiac contractility and function.
  • To explore the utility of relative heart sound amplitude ratios and exercise-induced changes.
  • To establish new methods for evaluating cardiac reserve and load.

Main Methods:

  • Developed four indicators: Cardiac Contractility Change Trend (CCCT) after exercise (CCCT(1/4), CCCT(1)), S1/S2 amplitude ratio, T1/M1 amplitude ratio, and Diastolic/Systolic duration ratio (D/S).

Related Experiment Videos

  • Collected data from a diverse group of volunteers undergoing exercise protocols.
  • Measured S1 and S2 amplitudes at rest and during varying exercise workloads.

    • Main Results:

    • CCCT(1/4) = 6.36 ± 3.01 (n=67), CCCT(1) = 10.36 ± 4.2 (n=33).
    • S1/S2 ratio = 1.89 ± 0.94 (n=140), T1/M1 ratio = 1.44 ± 0.99 (n=144), D/S ratio = 1.68 ± 0.27 (n=172).
    • Statistically significant values were obtained for all devised indicators.

    Conclusions:

    • CCCT indicators (CCCT(1/4), CCCT(1)) show promise for evaluating cardiac contractility and reserve mobilization.
    • S1/S2 ratio may help assess hypotension factors.
    • T1/M1 ratio is useful for right heart load assessment.
    • D/S ratio aids in evaluating diastolic cardiac blood perfusion time.