Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dystrophia myotonica. Peripheral nerve involvement and pathogenetic implications.

C P Panayiotopoulos, S Scarpalezos

    Journal of the Neurological Sciences
    |January 1, 1976
    PubMed
    Summary

    Dystrophia myotonica affects both nerves and muscles independently. Electrophysiological studies reveal peripheral nerve involvement, challenging the notion that muscle atrophy is solely neural in origin.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Migraine triggered seizures and epilepsy triggered headache and migraine attacks: a need for re-assessment.

    The journal of headache and pain·2011
    Same author

    The significance of specific diagnosis in the treatment of epilepsies.

    Developmental medicine and child neurology·2008
    Same author

    Improving the diagnostic yield in Panayiotopoulos syndrome.

    European journal of neurology·2008
    Same author

    Old versus new antiepileptic drugs: the SANAD study.

    Lancet (London, England)·2007
    Same author

    "Migralepsy" and the significance of differentiating occipital seizures from migraine.

    Epilepsia·2006
    Same author

    Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

    Neurology·2005

    Area of Science:

    • Neurology
    • Clinical Electrophysiology
    • Genetics

    Background:

    • Dystrophia myotonica is a multisystemic disorder.
    • The precise interplay between nerve and muscle pathology in dystrophia myotonica remains incompletely understood.

    Purpose of the Study:

    • To investigate peripheral nerve function in patients with dystrophia myotonica.
    • To compare electrophysiological findings with muscle involvement severity.

    Main Methods:

    • Comparative electrophysiological study of patients with dystrophia myotonica and controls.
    • Estimation of motor axons in the extensor digitorum brevis muscle.
    • Measurement of M- and F-wave conduction along the deep peroneal nerve.

    Main Results:

    Related Experiment Videos

    • Unequivocal electrophysiological evidence of peripheral nerve involvement was found.
    • Prolonged terminal latencies, slowed motor conduction, and delayed F-wave conduction were observed.
    • Reduced motor axons in the extensor digitorum brevis muscle were noted, with P < 0.001.

    Conclusions:

    • Nerve and muscle pathologies appear to be independently affected in dystrophia myotonica.
    • Muscle atrophy in dystrophia myotonica is not solely attributable to neural involvement.
    • Electrophysiological findings suggest a complex pathophysiology involving both neural and muscular components.