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Related Experiment Videos

Naltrexone improves outcome of a controlled drinking program.

Gabriel Rubio1, Jorge Manzanares, Francisco Lopez-Muñoz

  • 1Unidad de Conductas Adictivas, Servicio de Psiquiatria, Pabellon de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n,. 28041 Madrid, Spain. garuva@inicia.es

Journal of Substance Abuse Treatment
|December 24, 2002
PubMed
Summary

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Naltrexone combined with controlled drinking (NTX+CD) reduced alcohol consumption and craving compared to controlled drinking alone (CD). This suggests naltrexone aids in reducing heavy drinking days and craving in mild alcohol dependence.

Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Psychology

Background:

  • Naltrexone is primarily used for abstinence-based alcohol treatment.
  • Limited research exists on naltrexone's efficacy in reducing alcohol consumption.
  • Controlled drinking is an alternative therapeutic goal for alcohol dependence.

Purpose of the Study:

  • To evaluate naltrexone's effectiveness as an adjunct therapy in controlled drinking programs.
  • To compare a controlled drinking program with naltrexone (NTX+CD) against a controlled drinking program alone (CD).

Main Methods:

  • An open-label, randomized study over 12 weeks.
  • Involved 30 male patients with mild alcohol dependence per group.
  • Compared NTX+CD strategy versus CD strategy.

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Main Results:

  • No significant differences in drinking behavior during the 12-week treatment phase.
  • The NTX+CD group reported significantly less craving during treatment.
  • Follow-up showed NTX+CD had significantly fewer drinking days and heavy drinking days, with less craving.

Conclusions:

  • Naltrexone may play a role in augmenting controlled drinking programs.
  • Naltrexone shows potential for reducing alcohol consumption and craving in the long term.
  • This study supports naltrexone as an adjunct for individuals seeking to reduce alcohol intake.