Related Experiment Video
Updated: Sep 28, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Optimizing smoking cessation outcomes among the methadone maintained
Dominick L Frosch1, Deborah Nahom, Steve Shoptaw
1SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA 92182, USA. dfrosch@ucsd.edu
Abstract:
Several studies have shown high levels of interest in smoking cessation among methadone maintained heroin users, yet little is known about how to intervene most effectively with this population. The present study examined data from a large controlled trial of behavioral therapy in combination with nicotine replacement to find predictors of smoking cessation among the methadone maintained. Logistic regression analyses showed that less nicotine dependence, as measured by the Fägerstrom Test of Nicotine Dependence, and greater age were associated with higher rates of tobacco cessation. Greater opiate use, fewer nicotine patches used, and any tobacco smoking during weeks 2 and 3 of the intervention significantly negatively predicted smoking cessation outcomes.
Related Concept Videos
Drug Dependence
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
COPD: Management Using Bronchodilators and Corticosteroids
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
Chronic Obstructive Pulmonary Disease-V: Nursing Management
Assessment
Phase II Reactions: Methylation Reactions
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
