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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Feasibility of an HA2 domain-based periodontitis vaccine
A A DeCarlo1, Y Huang, C A Collyer
1Vaccine Research Division, Agenta Biotechnologies, Birmingham, Alabama 35253, USA. adecarlo@nova.edu
Infection and Immunity
|December 24, 2002
Abstract:
In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.
