Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Managing liver failure.

D A Kelly1

  • 1Liver Unit, Birmingham Children's Hospital NHS Trust, UK. Deirdre.Kelly@bhamchildrens.wmids.nhs.uk

Postgraduate Medical Journal
|December 24, 2002
PubMed
Summary
This summary is machine-generated.

Pediatric liver disease, though rare, requires prompt recognition and management. Advances in treatment, including liver transplantation, significantly improve outcomes for acute and chronic liver failure in children.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The necessity of education and hepatitis B vaccination for young people: A study of high risk behaviour for blood borne viruses in the United Kingdom.

Journal of child health care : for professionals working with children in the hospital and community·2019
Same author

A 10-year longitudinal follow-up study of a U.K. paediatric transplant population to assess for skin cancer.

The British journal of dermatology·2018
Same author

"Are these adult doctors gonna know me?" Experiences of transition for young people with a liver transplant.

Pediatric transplantation·2016
Same author

Parents in transition: Experiences of parents of young people with a liver transplant transferring to adult services.

Pediatric transplantation·2016
Same author

Selenium homocholic acid taurocholate scanning, selenium-75-labeled bile acid, a novel method for testing the function of the terminal ileum in small bowel transplant recipients: a pilot study.

Transplantation proceedings·2014
Same author

Treatment of chronic viral hepatitis C in children and adolescents: UK experience.

Archives of disease in childhood·2014
Same journal

Two cases of toxic epidermal necrolysis with severe ocular involvement treated with adjunctive tofacitinib.

Postgraduate medical journal·2026
Same journal

Diastolic dysfunction and diabetes: the DIADAD study-a retrospective cohort study from Liverpool.

Postgraduate medical journal·2026
Same journal

Care, cash, and proof: forensic accountability for war-related starvation.

Postgraduate medical journal·2026
Same journal

Response to traumatic injuries in polo players in England.

Postgraduate medical journal·2026
Same journal

Aids to venesection and parenteral drug administration in patients with difficult veins.

Postgraduate medical journal·2026
Same journal

Diagnostic reasoning in clinical neurology: a comprehensive primer.

Postgraduate medical journal·2026
See all related articles

Area of Science:

  • Pediatric Hepatology
  • Internal Medicine
  • Transplantation Medicine

Background:

  • Childhood liver disease presents unique challenges impacting natural history and outcomes.
  • Clinicians must be aware of evolving diagnostic and management strategies for pediatric liver conditions.

Purpose of the Study:

  • To highlight key developments in the management of acute and chronic liver failure in children.
  • To emphasize the importance of early diagnosis and timely referral for liver transplantation.

Main Methods:

  • Review of clinical presentations, common etiologies, and diagnostic criteria for pediatric liver failure.
  • Analysis of current supportive and definitive treatment modalities, including pharmacotherapy and liver transplantation.

Related Experiment Videos

Main Results:

  • Acute liver failure often stems from viral hepatitis, paracetamol overdose, or inherited metabolic disorders, presenting with jaundice, coagulopathy, and encephalopathy.
  • Chronic liver failure causes include neonatal conditions (biliary hypoplasia, biliary atresia) and autoimmune diseases or cystic fibrosis in older children.
  • Liver transplantation offers a 90% survival rate with good quality of life for pediatric liver failure.

Conclusions:

  • Early diagnosis and intervention are crucial to prevent severe complications like cerebral edema and renal failure.
  • Intravenous N-acetylcysteine can be effective in supportive management of acute liver failure.
  • Liver transplantation is the definitive treatment for many pediatric liver failure cases, necessitating early referral to specialized centers.