Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model for a smallpox-vaccination policy.

Samuel A Bozzette1, Rob Boer, Vibha Bhatnagar

  • 1RAND Center for Domestic and International Health Security, Santa Monica, Calif, USA.

The New England Journal of Medicine
|December 24, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving health sector coordination for resilient healthcare systems: European lessons from the COVID-19 pandemic.

Globalization and health·2026
Same author

Supportive care interventions in hematopoietic stem cell transplantation: a systematic review and meta-analysis.

Blood advances·2026
Same author

SARS-CoV-2 N protein and anti-spike serologies: insights into COVID-19 disease severity and mortality-a secondary analysis of the ACTIV-1 trial.

Therapeutic advances in infectious disease·2025
Same author

Regional variations in Italy's COVID-19 death toll: a descriptive analysis of excess mortality and associated factors from 2020 to 2021.

Population health metrics·2025
Same author

Resource Use in the Randomized Master Protocol for Immune Modulators for Treating COVID-19 (ACTIV-1 IM): A Secondary Data Analysis.

CHEST critical care·2024
Same author

Efficacy of infliximab, abatacept, and cenicriviroc for the treatment of adults hospitalized with COVID-19 pneumonia.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2024

Prioritizing smallpox vaccination for healthcare workers is recommended unless attack likelihood is very low. Public vaccination is only favored if national or multiple attacks are highly probable.

Area of Science:

  • Epidemiology
  • Biosecurity
  • Public Health Policy

Background:

  • The threat of bioterrorism necessitates re-evaluating smallpox vaccination policies.
  • Smallpox (variola virus) remains a potential bioweapon.

Observation:

  • A stochastic model simulated smallpox attack scenarios and control strategies.
  • Systematic literature review informed model parameters using historical outbreaks.
  • Analysis assessed risks of vaccine-related harms versus benefits.

Findings:

  • Attack scenarios varied in complexity and impact, influencing spread patterns.
  • Contact vaccination plus isolation is crucial for mitigating outbreaks.
  • Prioritizing healthcare worker vaccination offers significant life-saving benefits in various attack scenarios, with minimal fatalities.

Related Experiment Videos

  • Widespread public vaccination provides limited additional benefit and carries higher risks.

    • Implications:

    • The findings support targeted pre-vaccination of healthcare workers against smallpox.
    • Public vaccination is justifiable only under conditions of high probability for national or multiple attacks.
    • These insights inform biodefense strategies and pandemic preparedness.