Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumor microenvironment and the response to anticancer therapy.

J Martin Brown1

  • 1CCSR 1255, Division of Radiation and Cancer Biology, Dept. of Radiation Oncology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA. mbrown@stanford.edu

Cancer Biology & Therapy
|December 24, 2002
PubMed
Summary

Solid tumors often lack oxygen (hypoxia) and develop necrotic regions, offering unique therapeutic targets. Exploiting these tumor characteristics, particularly hypoxia, presents promising new strategies for cancer treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Macrophage Exclusion after Radiation Therapy (MERT): A First-in-Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2023
Same author

Reflections of the Senior Editors for Biology.

International journal of radiation oncology, biology, physics·2021
Same author

In Reply to Song et al, and In Reply to Brown and Carlson.

International journal of radiation oncology, biology, physics·2021
Same author

In Regard to Nam et al.

International journal of radiation oncology, biology, physics·2021
Same author

Cell Killing and Chromosome Aberrations by Ionizing Radiations: Brother, Can You Paradigm?

International journal of radiation oncology, biology, physics·2020
Same author

In Regard to Song et al.

International journal of radiation oncology, biology, physics·2020

Area of Science:

  • Oncology
  • Cancer Biology
  • Therapeutic Strategies

Background:

  • Human solid tumors exhibit significantly lower oxygen levels compared to normal tissues.
  • Tumor hypoxia and associated necrosis are distinct characteristics differentiating tumors from healthy tissues.
  • These differences present exploitable vulnerabilities for targeted cancer therapies.

Purpose of the Study:

  • To review the phenomenon of tumor hypoxia and its accompanying necrosis.
  • To explore therapeutic strategies that exploit these tumor characteristics for cancer treatment.

Main Methods:

  • Discussion of drugs selectively toxic under hypoxic conditions, exemplified by tirapazamine.
  • Exploration of gene therapy strategies leveraging hypoxia-inducible factor 1 (HIF-1) induction.

Related Experiment Videos

  • Review of engineered obligate anaerobes for targeted prodrug activation within hypoxic tumor environments.

    • Main Results:

    • Tirapazamine, a hypoxia-activated drug, shows promise in early clinical trials.
    • Gene therapy approaches targeting HIF-1 are under development.
    • Engineered anaerobic bacteria demonstrate potential for localized chemotherapy delivery.

    Conclusions:

    • Tumor hypoxia and necrosis are critical, exploitable features in solid tumors.
    • Targeted therapeutic strategies, including hypoxia-activated drugs, gene therapy, and anaerobic bacteria, offer novel treatment avenues.