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Body composition in aging: a biological perspective.

Richard N Pierson¹

¹Nutrition Research Center, St Lukes Roosevelt Hospital Center, 1111 Amsterdam Avenue at 114th Street, New York, NY 10025, USA. mpl@columbia.edu

Current Opinion in Clinical Nutrition and Metabolic Care

|December 24, 2002

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Aging impacts body composition, leading to reduced body cell mass and increased medical risks. Research into molecular aging, particularly reactive oxygen species, offers insights for interventions and lifespan prediction.

Area of Science:

Gerontology
Molecular Biology
Physiology

Background:

Aging significantly alters body composition, notably decreasing body cell mass.
These body composition changes are linked to and predict medical and surgical risks.
Interventions targeting age-related body composition changes are being explored.

Purpose of the Study:

To review the impact of aging on body composition.
To explore the molecular biology of aging and its implications.
To identify intersections between clinical and fundamental science fields.

Main Methods:

Review of current research on aging and body composition.
Analysis of molecular, genetic, and proteomic data related to aging.
Examination of reactive oxygen and nitrogen species toxicity, particularly in mitochondria.

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Main Results:

Molecular biology of aging is a rapidly advancing research area.
Mitochondrial toxicities from reactive oxygen and nitrogen species can be studied at multiple scales.
These findings have implications for patient management and lifespan prediction.

Conclusions:

Interdisciplinary research is crucial, integrating endocrinology, nuclear medicine/radiology, geriatrics, physiology, molecular biology, genetics, and proteomics.
Understanding molecular aging mechanisms can inform therapeutic strategies.
This integrated approach is key to managing age-related changes and predicting health outcomes.