Related Experiment Video
Updated: Aug 11, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Local therapy for prostate-specific antigen recurrence after definitive treatment
1Department of Urology, University of California San Francisco School of Medicine, San Francisco, CA.
Prostate Cancer and Prostatic Diseases
|December 24, 2002
Summary
Recurrent prostate cancer after initial treatment is common, with rising prostate-specific antigen (PSA) as an early indicator. Identifying at-risk patients and localizing recurrence aids in selecting appropriate salvage therapies to improve outcomes.
Area of Science:
- Oncology
- Urology
- Medical Imaging
Background:
- Prostate cancer recurrence after local therapy is a frequent clinical challenge.
- Rising prostate-specific antigen (PSA) levels are the primary early indicator of disease recurrence.
Purpose of the Study:
- To review clinical and pathological factors predicting treatment failure in prostate cancer.
- To discuss the role of PSA kinetics and imaging in localizing recurrent prostate cancer.
- To outline salvage treatment options for recurrent prostate cancer.
Main Methods:
- Analysis of clinical and pathological factors associated with treatment failure.
- Evaluation of prostate-specific antigen (PSA) characteristics for recurrence detection.
- Review of imaging modalities for localizing recurrent disease.
- Compilation of available salvage treatment options based on prior therapy.
Main Results:
- Clinical and pathological factors help identify patients at high risk for treatment failure.
- PSA levels and imaging studies are crucial for localizing recurrent prostate cancer.
- Various salvage therapies exist depending on the initial treatment (prostatectomy or radiotherapy).
Conclusions:
- Accurate identification of recurrence and patient risk stratification are key to successful salvage therapy.
- Salvage options include radiation therapy, cryoablation, and surgery.
- Ongoing research into novel modalities aims to enhance salvage therapy efficacy and reduce morbidity.
