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Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jul 25, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

High risk genes predisposing to prostate cancer development-do they exist?

R Singh1, R A Eeles, F Durocher

  • 1Institute of Cancer Research, Sutton, Surrey, UK.

Prostate Cancer and Prostatic Diseases
|December 24, 2002
PubMed
Summary

Genetic predisposition plays a role in prostate cancer, but identifying specific genes is challenging. Advances in genomics and robotics are expected to aid in discovering these multiple, low-penetrance prostate cancer genes.

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Area of Science:

  • Genetics
  • Oncology
  • Genomic Medicine

Background:

  • Prostate cancer exhibits genetic predisposition, yet identifying causative genes has lagged behind other common cancers.
  • The complexity of prostate cancer genetics presents significant research challenges.

Purpose of the Study:

  • To discuss the reasons behind the difficulty in identifying prostate cancer genes.
  • To highlight the emerging understanding of prostate cancer as a polygenic disease.
  • To explore how technological advancements can overcome these genetic research hurdles.

Main Methods:

  • Review and discussion of existing evidence on prostate cancer genetics.
  • Analysis of challenges in gene identification for prostate cancer.
  • Consideration of the impact of the Human Genome Project and robotic technologies.

Main Results:

  • Prostate cancer is likely influenced by multiple genes, often with moderate or low penetrance.
  • Identifying these genes is more complex than for breast or colon cancer.

Conclusions:

  • The genetic architecture of prostate cancer is complex, involving numerous genes with varying penetrance.
  • Technological progress, including the Human Genome Project and robotics, is crucial for advancing prostate cancer gene discovery.