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Related Experiment Videos

Using splines to detect changes in PSA doubling times.

Brad Guess1, Robert Jennrich, Henry Johnson

  • 1Healing Touch Oncology, Marina del Rey, California, USA. brad@prost8cancer.com

The Prostate
|December 24, 2002
PubMed
Summary

A new method estimates prostate-specific antigen doubling time (PSADT) before and after therapy, determining if changes are statistically significant. This approach helps assess treatment effectiveness in prostate cancer patients with biochemical relapse.

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Biopsy for Prostate Cancer Diagnosis.

The New England journal of medicine·2020

Area of Science:

  • Oncology
  • Biostatistics

Background:

  • Prostate-specific antigen doubling time (PSADT) predicts clinical progression in prostate cancer patients with biochemical relapse.
  • Assessing changes in PSADT in response to therapy is crucial for clinical and investigational purposes.
  • Current methods may not adequately determine the statistical significance of PSADT changes.

Purpose of the Study:

  • To present a novel statistical method for estimating PSADT before and after therapy.
  • To determine the statistical significance of observed changes in PSADT.
  • To provide a tool for evaluating treatment response in individual prostate cancer patients.

Main Methods:

  • Utilizes a best-fitting spline (broken-line approximation) of log PSA versus time to estimate PSADT.
  • Employs linear regression to fit the model and assess the statistical significance of PSADT changes.

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  • This method integrates all available data and accounts for PSA continuity at treatment initiation.

    • Main Results:

    • The technique was illustrated using data from a pilot study of 12 men with prostate cancer receiving a nutritional supplement.
    • Analysis of the first patient demonstrated the data handling and interpretation of doubling times and significance.
    • Nine out of 12 patients showed a statistically significant increase in PSADT, indicating a positive response.

    Conclusions:

    • The presented method for PSADT change evaluation is simple and widely applicable.
    • It enables the assessment of the magnitude and statistical significance of PSADT changes post-therapy.
    • The method is compatible with standard statistical software and accepted statistical principles.