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Development of skin interfacing cannula.

C W Hall, L M Adams, J J Ghidoni

    Transactions - American Society for Artificial Internal Organs
    |January 1, 1975
    PubMed
    Summary
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    Nylon and Dacron velours show promise for long-term skin interfacing materials. A unique "growth phenomenon" was observed, where cell maturation integrates fibers, potentially improving implant integration.

    Area of Science:

    • Biomaterials Science
    • Polymer Science
    • Tissue Engineering

    Background:

    • Developing long-term skin-interfacing materials is crucial for medical implants.
    • Various polymer surfaces (velours, felts, foams) were evaluated for biocompatibility.
    • Understanding cellular interactions with implant surfaces is key to success.

    Purpose of the Study:

    • To investigate the skin interfacing potential of different polymer materials.
    • To assess the long-term performance of implantable materials in animal models.
    • To identify materials suitable for stable, long-term skin penetration.

    Main Methods:

    • Bonding various polymer surfaces (nylon, Dacron velours, felts, foams) to silastic rods using medical adhesive.
    • Implanting these polymer-coated rods (dummy cannulae) onto the dorsum of canines, goats, and swine.

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  • Evaluating over 200 implants, some retained for up to 2 years, including vitreous carbon buttons.

    • Main Results:

    • Nylon and Dacron velours demonstrated significant promise as long-term skin interfacing materials.
    • A notable "growth phenomenon" was observed with velour materials, linked to cellular integration.
    • Basal cells appeared to bond with monofilament fibers, leading to cannula surface migration and apparent growth.

    Conclusions:

    • Nylon and Dacron velours are promising candidates for long-term skin interfacing applications.
    • The observed "growth phenomenon" suggests a mechanism for enhanced implant integration and stability.
    • While maturation rates differ between species, the findings support the potential application of velour materials in humans.