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Left ventricular hypertrophy regression: the LIVE trial

D J Sheridan1

  • 1Academic Cardiology Unit, Division of NHLI, Imperial College School of Medicine, St Mary's Hospital, Queen Elizabeth the Queen Mother Wing, London W2 1NY, UK.

Cardiologia (Rome, Italy)
|December 25, 2002
PubMed

Insights

The LIVE study found that indapamide effectively reduced left ventricular hypertrophy (LVH) in hypertensive patients over one year. This diuretic demonstrated efficacy comparable to enalapril in LVH regression.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Trials

Background:

  • Left ventricular hypertrophy (LVH) increases vascular event risk.
  • Diuretic efficacy for LVH reduction is debated.
  • Antihypertensive treatments are evaluated for LVH regression.

Purpose of the Study:

  • To compare indapamide versus enalapril for LVH regression in hypertensive patients.
  • To assess the efficacy of indapamide 1.5 mg daily and enalapril 20 mg daily.
  • To evaluate LVH reduction after one year of treatment.

Main Methods:

  • Prospective, double-blind, randomized controlled trial (LIVE study).
  • Inclusion criteria: Hypertensive patients with LVH.
  • Echocardiography used for LVH assessment, with blind reading by an independent committee.

Main Results:

  • Preliminary data confirm indapamide's antihypertensive efficacy.
  • Indapamide showed efficacy in reducing left ventricular mass.
  • Progressive LVH reduction observed over one year with indapamide.

Conclusions:

  • Indapamide is effective in reducing left ventricular hypertrophy in hypertensive patients.
  • The study provides evidence for indapamide's role in managing LVH.
  • Indapamide offers a viable treatment option for hypertensive patients with LVH.

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