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Updated: Sep 28, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
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Therapeutic inhibitors of tumor necrosis factor in Crohn's disease

Srinivasan Ganesan1, Simon P L Travis, Tariq Ahmad

  • 1Phase 1 Clinical Trials Unit, 119 Looseleigh Lane, Derriford, Plymouth, PL6 5HH, UK.

Current Opinion in Investigational Drugs (London, England : 2000)
|December 25, 2002
PubMed

Therapeutic options for patients with refractory ulcerative colitis or Crohn's disease have recently been augmented by the introduction of biological therapies. The pro-inflammatory cytokine, tumor necrosis factor (TNF)-alpha is present in elevated concentrations in patients with inflammatory bowel disease and inhibitors of TNF alpha have proved effective as treatment. Strategies aimed at reducing TNF in patients with Crohn's disease, include the mouse/human chimeric monoclonal antibody, infliximab (Centocor Inc), the humanized monoclonal antibody, CDP-571 (Celltech Group plc), the human recombinant TNF receptor fusion protein, etanercept (Immunex Corp), and thalidomide. New approaches, including the use of soluble TNF receptors, appear promising. This article reviews the evidence of therapeutic inhibition of TNF.

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