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S-18886 Servier
Stavros K Kakkos1, Andrew N Nicolaides
1Irvine Laboratory for Cardiovascular Investigation and Research, Department of Vascular Surgery, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 10th Floor QEQM Wing, St Mary's Hospital, London, W2 1NY, UK. s.kakkos@ic.ac.uk
Current Opinion in Investigational Drugs (London, England : 2000)
|December 25, 2002
Summary
S-18886 is a long-acting thromboxane A2 receptor antagonist being developed for cardiovascular diseases. Clinical trials in coronary artery disease patients were underway by 2001.
Area of Science:
- Cardiovascular pharmacology
- Drug development
Background:
- Thromboxane A2 (TXA2) plays a role in cardiovascular diseases.
- TXA2 receptor antagonists are a therapeutic target.
Purpose of the Study:
- To evaluate S-18886, a potent TXA2 receptor antagonist.
- To assess the potential of S-18886 in treating cardiovascular conditions.
Main Methods:
- S-18886 is the active isomer of S-18204.
- Clinical trials were conducted in patients with coronary artery disease.
Main Results:
- S-18886 demonstrated a long duration of action.
- Clinical trials progressed, with advanced studies ongoing in 2001.
Conclusions:
- S-18886 shows promise as a treatment for cardiovascular diseases.
- Further development and clinical evaluation are warranted.
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