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Utilizing brain imaging for analgesic drug development.

David Borsook1, Alexander Ploghaus, Lino Becerra

  • 1Center for Functional Pain Neuroimaging and Therapy Research, NMR Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA. borsook@nmr.mgh.harvard.edu

Current Opinion in Investigational Drugs (London, England : 2000)
|December 25, 2002
PubMed
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Current analgesics effectively manage acute pain, but chronic pain relief remains challenging due to a lack of objective pain and analgesic evaluation methods. Functional brain imaging offers a promising solution for objective assessment and improved drug development.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Medical Imaging

Background:

  • Analgesia, the relief of pain without loss of consciousness, is effective for acute pain but not chronic pain.
  • Current analgesics for chronic pain often have limited efficacy and problematic side effect profiles.
  • Objective methods for pain assessment, analgesic efficacy correlation between species, and evaluation in conditions like neuropathic pain are lacking.

Purpose of the Study:

  • To address the limitations in current pain and analgesic assessment.
  • To explore the potential of functional brain imaging for objective pain evaluation.
  • To revolutionize preclinical and clinical drug development for analgesics.

Main Methods:

  • Utilizing advancements in functional brain imaging technology.

Related Experiment Videos

  • Applying these techniques to both human and animal models.
  • Developing objective methods for evaluating pain states and analgesic efficacy.

    • Main Results:

    • Functional brain imaging provides new avenues for objective pain and analgesic evaluation.
    • These methods offer a potential solution to the lack of objective assessment tools.
    • The technology holds promise for improving the drug development pipeline.

    Conclusions:

    • Functional brain imaging represents a significant technological advancement for pain research.
    • Objective evaluation of analgesics and pain states is achievable with these new approaches.
    • This technology is poised to transform the development of new pain management therapies.