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[Some aspects of evaluating endogenous intoxication in patients with acute dysentery]

B S Nagoev, M Iu Marzhokhova

    Terapevticheskii Arkhiv
    |December 25, 2002
    PubMed
    Abstract

    Insights

    Endogenic intoxication in acute dysentery (AD) patients was evaluated by measuring low and medium molecular mass (LM and MM) substances. Higher concentrations were observed during illness, decreasing as symptoms resolved, indicating intoxication severity.

    Area of Science:

    • Biochemistry
    • Clinical Medicine
    • Toxicology

    Context:

    • Acute dysentery (AD) is a significant public health concern, often associated with systemic complications.
    • Endogenic intoxication, characterized by the accumulation of harmful substances, is a key factor in disease pathogenesis.
    • Assessing specific biomarkers is crucial for understanding disease severity and progression.

    Purpose:

    • To quantify low and medium molecular mass (LM and MM) substances in various bodily fluids of patients with acute dysentery.
    • To correlate the levels of these substances with the clinical course and severity of acute dysentery.
    • To evaluate LM and MM substances as indicators of endogenic intoxication in AD.

    Summary:

    • Patients with acute dysentery exhibited significantly elevated concentrations of LM and MM substances in plasma, red blood cells, and urine compared to healthy individuals.
    • These substance levels decreased as clinical symptoms subsided, returning to normal in red cells and urine during early convalescence, though remaining elevated in plasma.
    • The most pronounced changes in LM and MM substance concentrations were observed in patients with severe cases of acute dysentery.

    Impact:

    • The concentration of LM and MM substances in blood plasma, red cells, and urine is dependent on the disease stage and severity in acute bacterial dysentery.
    • These findings suggest that LM and MM substances can serve as valuable indicators for assessing the degree of endogenic intoxication in AD patients.
    • This research provides a basis for developing more targeted therapeutic strategies for managing endogenic intoxication in infectious diseases.

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