Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dantrolene diminishes forelimb force-related tremor at doses that do not decrease operant behavior in the rat.

John A Stanford1, Stephen C Fowler

  • 1Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center, Lexington 40536-0098, USA. jastan2@uky.edu

Experimental and Clinical Psychopharmacology
|December 25, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Donepezil treatment, alone or combined with exercise, enhances skeletal muscle function in healthy and advanced aging disease mouse models.

Journal of applied physiology (Bethesda, Md. : 1985)·2025
Same author

Understanding the Pre-Clinical Stages of Parkinson's Disease: Where Are We in Clinical and Research Settings?

International journal of molecular sciences·2025
Same author

Intrinsic aerobic capacity modulates Alzheimer's disease pathological hallmarks, brain mitochondrial function and proteome during aging.

GeroScience·2024
Same author

Current Perspectives: Obesity and Neurodegeneration - Links and Risks.

Degenerative neurological and neuromuscular disease·2024
Same author

Forelimb Resistance Exercise Protects Against Neuromuscular Junction Denervation in the SOD1-G93A Rat Model of ALS.

Degenerative neurological and neuromuscular disease·2022
Same author

Biophysical analyses of rodent behavior in neuroscience research: A tribute to Dr. Stephen C. Fowler.

Brain research bulletin·2022
Same journal

Gimmie the Gummies: Initial validation of the Edibles Marijuana Purchase Task.

Experimental and clinical psychopharmacology·2026
Same journal

Feasibility and acceptability of a trauma-informed and peer-supported digital brief intervention for heavy-drinking emerging adults with interpersonal trauma.

Experimental and clinical psychopharmacology·2026
Same journal

App-based contingency management to reduce heavy drinking days among smokers receiving varenicline: Feasibility, acceptability, and efficacy indicators from a phase I analog trial.

Experimental and clinical psychopharmacology·2026
Same journal

Innovations in health behavior research: Current status and strategic future directions.

Experimental and clinical psychopharmacology·2026
Same journal

Cannabis cues, motives, and attention enhancement: A cannabis priming pilot study.

Experimental and clinical psychopharmacology·2026
Same journal

Effects of the neuroactive steroid precursor pregnenolone on stress- and alcohol cue-provoked pain responses in individuals with alcohol use disorder.

Experimental and clinical psychopharmacology·2026
See all related articles

Dantrolene sodium, a muscle relaxant, reduced forelimb tremor and improved fine motor control in rats at tested doses. The drug effectively decreased tremor without causing behavioral suppression, indicating potential neuroprotective benefits.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Dantrolene sodium is a muscle relaxant with potential neuroprotective properties.
  • Assessing its effects on fine motor control and tremor is crucial for understanding its therapeutic applications.

Purpose of the Study:

  • To evaluate the impact of dantrolene sodium on forelimb force production and tremor in a rodent model.
  • To determine if dantrolene sodium affects motor control at doses that do not cause behavioral suppression.

Main Methods:

  • A behavioral preparation was established for concurrent measurement of forelimb force and tremor in rats.
  • Rats were trained to press an isometric force transducer while receiving water reinforcement.
  • Dantrolene sodium was administered at doses of 5.0, 7.5, and 10.0 mg/kg.

Related Experiment Videos

Main Results:

  • Dantrolene sodium diminished force output at 7.5 and 10.0 mg/kg doses.
  • Tremor was decreased at all tested doses (5.0, 7.5, and 10.0 mg/kg).
  • The ratio of forelimb tremor to force output was reduced across all doses, with no observed behavioral suppression.

Conclusions:

  • Dantrolene sodium effectively reduces tremor in rats at therapeutic doses.
  • The drug appears to enhance fine motor control without causing significant behavioral impairment.
  • These findings support the potential of dantrolene sodium as a neuroprotective agent for motor control disorders.