Related Experiment Video
Updated: Sep 28, 2026
Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
Published on: April 11, 2018
Nasal polyposis in children with cystic fibrosis: a long-term follow-up study
Matthew W Yung1, Jim Gould, Graham J G Upton
1Department of Otolaryngology-Head and Neck Surgery, The Ipswich Hospital NHS Trust, Ipswich, England, United Kingdom.
Insights
Nasal polyposis is common in children with cystic fibrosis (CF), with over half affected. While surgery offers initial relief, many children with CF experience polyp recurrence, often requiring repeat procedures.
Area of Science:
- Pediatric Otolaryngology
- Respiratory Medicine
- Genetics and Hereditary Diseases
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs, including the respiratory system.
- Nasal polyposis is a frequent complication in CF patients, impacting airway function and quality of life.
- Understanding the prevalence and surgical outcomes of nasal polyposis in pediatric CF is crucial for management.
Purpose of the Study:
- To determine the incidence of nasal polyposis in children diagnosed with cystic fibrosis (CF).
- To evaluate the outcomes and recurrence rates following endoscopic sinus surgery for nasal polyposis in this pediatric population.
- To provide data for parental counseling regarding surgical interventions for CF-related nasal polyposis.
Main Methods:
- Systematic examination of all children aged 5-18 on a local CF register.
- Endoscopic assessment for nasal polyposis and CT scans for sinus evaluation.
- Review of surgical records for radical endoscopic sinus surgery (1989-2000) and follow-up for recurrence.
Main Results:
- 13 out of 23 children (56.5%) with CF exhibited endoscopic evidence of nasal polyposis (Grade 2 or 3).
- Complete maxillary sinus opacity was observed in 21/23 children; only 1 had a developed frontal sinus.
- 7 out of 12 children who underwent surgery required revision surgery due to recurrent nasal polyps, with a median interval of 4 years.
Conclusions:
- Nasal polyposis is highly prevalent in children with cystic fibrosis.
- Endoscopic sinus surgery provides initial improvement but has a high recurrence rate in this population.
- Findings aid in counseling parents about the long-term management of nasal polyps in pediatric CF patients.
Abstract:
The incidence of nasal polyposis among children 5 to 18 years of age with cystic fibrosis (CF) was investigated with a systematic examination of all children on the local CF register. Out of 23 children with CF, 13 had endoscopic evidence of nasal polyposis. Four children had grade 2 polyposis, and 9 children had grade 3 polyposis. Complete opacity of the maxillary sinus was identified on a computed tomographic sinus scan in all but 2 of the children. Only 1 child had a developed frontal sinus. Between 1989 and 2000, 12 children underwent radical endoscopic sinus surgery for their nasal polyposis. There was good postoperative improvement in all of the children; however, 7 eventually required revision surgery because of recurrence of the nasal polyps. The median interval between repeated sinus surgeries was 4 years (range, 18 months to more than 6 years). This information can help in the counseling of parents when sinus surgery is considered for children with CF.
Related Concept Videos
01:23Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features