Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olfactory axons: a remarkable convergence.

Asaf Hellman1, Andrew Chess

  • 1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.

Current Biology : CB
|December 25, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes.

Science (New York, N.Y.)·2024
Same author

Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation.

Genome biology·2023
Same author

Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases.

Scientific data·2023
Same author

Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent <i>NRXN1</i> and <i>ABCB11</i> disruptions.

Cell genomics·2023
Same author

Sex Differences in the Human Brain Transcriptome of Cases With Schizophrenia.

Biological psychiatry·2021
Same author

Comprehensive identification of somatic nucleotide variants in human brain tissue.

Genome biology·2021
Same journal

A global response contributes to tissue size robustness upon local induction of apoptosis.

Current biology : CB·2026
Same journal

Prebilaterian origin of monoaminergic signaling.

Current biology : CB·2026
Same journal

CLASP-dependent microtubule stabilization generates microtubule-based protrusive forces during Drosophila epithelial morphogenesis.

Current biology : CB·2026
Same journal

Pigeons make slow, divergent eye movements during flight and large, convergent eye movements when landing.

Current biology : CB·2026
Same journal

Temperature signals drive grass secondary cell wall thickening.

Current biology : CB·2026
Same journal

Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress.

Current biology : CB·2026
See all related articles

Neural circuits in the mouse olfactory bulb show interdependence during development. This study supports the idea that connections between neurons mature through coordinated interactions.

Area of Science:

  • Neuroscience
  • Olfactory system development

Background:

  • Thousands of neurons expressing a single mouse odorant receptor converge onto a few glomeruli in the olfactory bulb.
  • The precise mechanisms governing this precise neural wiring remain incompletely understood.

Purpose of the Study:

  • To investigate the role of interdependence in the maturation of olfactory sensory maps.
  • To provide evidence supporting the hypothesis that coordinated interactions are crucial for neural convergence.

Main Methods:

  • Utilized genetically modified mice expressing small odorant receptor transgenes.
  • Observed the developmental patterns of neural projections in the olfactory bulb.

Main Results:

  • New observations provide support for the interdependence hypothesis.

Related Experiment Videos

  • Demonstrated that the convergence of olfactory receptor neurons is a coordinated process.

    • Conclusions:

    • Interdependence plays a significant role in the maturation of the olfactory sensory map.
    • The convergence of olfactory neurons is not solely driven by individual receptor-glomerulus specificity but involves broader circuit interactions.