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Combinatorial glycosylation of glycopeptide antibiotics
1Natural Products Research, Cubist Pharmaceuticals, Lexington, MA 02421, USA.
Chemistry & Biology
|December 25, 2002
Abstract:
The glycosyltransferases GtfE and GtfD from the vancomycin producer Amycolatopsis orientalis have promiscuous substrate and NDP-sugar specificities. They have been used to generate novel glycopeptide antibiotics containing the heptapeptide scaffolds of vancomycin and teichoplanin.