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Related Experiment Videos

Gabapentin in late-onset poststroke seizures.

J Alvarez-Sabín1, J Montaner, L Padró

  • 1Cerebrovascular Unit, Department of Neurology, Hospital Vall d'Hebron, Barcelona, Spain. alsa@hg.vhebron.es

Neurology
|December 25, 2002
PubMed
Summary

Gabapentin is effective and safe for adults experiencing late epileptic seizures (ES) after a stroke. Long-term use showed a low recurrence rate of ES and minimal side effects, making it a viable treatment option.

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Area of Science:

  • Neurology
  • Clinical Pharmacology

Background:

  • Stroke is a primary cause of adult-onset epileptic seizures (ES).
  • Late poststroke seizures require effective long-term management strategies.

Purpose of the Study:

  • To assess the long-term efficacy and tolerability of gabapentin in patients with first late poststroke epileptic seizures.
  • To evaluate gabapentin monotherapy for managing late poststroke ES.

Main Methods:

  • A cohort of 71 patients with first late poststroke ES were treated with gabapentin (900-1,800 mg/day).
  • The study involved a mean follow-up period of 30 months.

Main Results:

  • Epileptic seizure recurrence was observed in 18.3% of patients.
  • Adverse side effects were reported in 38% of cases, with only 2.8% requiring treatment discontinuation.

Related Experiment Videos

  • Gabapentin demonstrated a favorable safety profile with minimal treatment withdrawals.

    • Conclusions:

    • Gabapentin monotherapy is a useful and safe treatment for late poststroke epileptic seizures.
    • The drug offers a good balance between efficacy and tolerability for this patient population.