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Chemical modification of coumarin dimer and HIV-1 integrase inhibitory activity
Pili Chih-Min Mao1, Jean-Francois Mouscadet, Herve Leh
1Department of Pharmacy, Veterans General Hospital Kaohsiung, Taipei, Tawain, ROC.
Chemical & Pharmaceutical Bulletin
|December 25, 2002
Abstract:
A systematic series of chemically modified coumarin dimmers has been synthesized and tested for their inhibitory activity against HIV-1 integrase. We observed that modified coumarin dimmers containing hydrophobic moiety on the linker display potent inhibitory activities.