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Left and right coronary circulation in left ventricular hypertrophy: effects of angiotensin converting enzyme

Yasuyuki Shimada1, Metin Avkiran

  • 1Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Japan. yasuyuki.shimada@ma8.seikyou.ne.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|December 25, 2002
PubMed

Insights

Angiotensin converting enzyme (ACE) inhibitors like ramipril can improve coronary circulation in rats with left ventricular hypertrophy by lowering blood pressure. However, they did not reduce heart muscle enlargement or affect left coronary flow.

Area of Science:

  • Cardiovascular Physiology
  • Pharmacology

Background:

  • Left ventricular (LV) hypertrophy, often caused by pressure overload, can impair coronary circulation.
  • Understanding the effects of interventions on coronary blood flow in this condition is crucial.

Purpose of the Study:

  • To investigate the impact of ramipril, an ACE inhibitor, on coronary circulation in a rat model of pressure overload-induced LV hypertrophy.
  • To determine if ramipril affects coronary vascular resistance in the left and right coronary beds.

Main Methods:

  • Rats underwent abdominal aortic constriction or sham surgery.
  • Rams were treated with vehicle or varying doses of ramipril.
  • Blood pressure, LV weight, and minimum coronary vascular resistance (MCVR/g) were measured.

Main Results:

  • Aortic constriction increased blood pressure, LV weight, and bilateral MCVR/g.
  • Ramipril dose-dependently reduced blood pressure and improved right coronary circulation.
  • Ramipril did not alter LV mass or left coronary vascular resistance.

Conclusions:

  • Both coronary hypertension and myocardial hypertrophy contribute to impaired coronary circulation in LV hypertrophy.
  • ACE inhibitors may benefit coronary circulation in LV hypertrophy at appropriate doses.

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