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Fenprostalene-induced abortion in bitches
Tatsuya Hori1, Takako Akikawa, Eiichi Kawakami
1Department of Reproduction, Nippon Veterinary and Animal Science University, Tokyo, Japan.
The Journal of Veterinary Medical Science
|December 25, 2002
Summary
Fenprostalene, a prostaglandin analogue, can induce abortion in pregnant dogs when administered mid-pregnancy. Aborted dogs experienced earlier subsequent estrus with a reduced conception rate.
Area of Science:
- Veterinary Medicine
- Reproductive Biology
- Pharmacology
Background:
- Prostaglandin F(2alpha) analogues are used in veterinary medicine for reproductive management.
- Fenprostalene is a long-acting analogue with potential abortifacient properties in canines.
Purpose of the Study:
- To evaluate the efficacy and safety of fenprostalene for inducing abortion in mid-pregnant bitches.
- To assess the impact of fenprostalene on plasma progesterone levels, estrus interval, and subsequent conception rates.
Main Methods:
- Subcutaneous administration of fenprostalene at varying doses (5-150 microg) on day 25 post-ovulation in pregnant bitches.
- Monitoring of pregnancy maintenance, plasma progesterone concentrations, and intervals to subsequent estrus and conception.
Main Results:
- Fenprostalene induced dose-dependent abortions, with 50 microg or higher causing complete abortion in all treated dogs.
- Abortion correlated with a drop in plasma progesterone below 2 ng/ml.
- Aborted bitches exhibited significantly shorter intervals to subsequent estrus and a 50% conception rate, compared to non-aborted controls.
Conclusions:
- A single dose of fenprostalene can effectively induce abortion in mid-pregnant bitches.
- Fenprostalene treatment can lead to earlier subsequent estrus with a decreased conception rate in canines.