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Elevated plasma antidiuretic hormone levels in status asthmaticus.
Mayo Clinic Proceedings
|January 1, 1976
Summary
Patients with status asthmaticus may experience elevated antidiuretic hormone (ADH) levels, potentially impacting fluid therapy. These levels normalize as the condition resolves, suggesting a link to bronchospasm and reduced blood flow.
Area of Science:
- Pulmonary Medicine
- Endocrinology
Background:
- Status asthmaticus is a severe asthma exacerbation.
- Altered mental status in asthma patients can be multifactorial.
Purpose of the Study:
- To investigate plasma antidiuretic hormone (ADH) levels in patients with status asthmaticus.
- To explore the potential mechanisms and clinical implications of elevated ADH during severe asthma.
Main Methods:
- Measured plasma ADH levels in seven patients during acute status asthmaticus.
- Monitored ADH levels as patients recovered.
Main Results:
- Elevated plasma ADH levels were observed in all seven patients during the acute phase.
- ADH levels returned to normal with clinical improvement.
- The findings support a hypothesis linking bronchospasm to reduced atrial volume and subsequent ADH release.
Conclusions:
- Increased plasma ADH is common in status asthmaticus.
- Fluid management in these patients should consider potential ADH-mediated water retention.
- Water intoxication, hypoxia, and hypercarbia are important considerations for altered consciousness in status asthmaticus.