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Related Experiment Videos

Beyond the visible--imaging the human brain with light.

Hellmuth Obrig1, Arno Villringer

  • 1Department of Neurology, Charité, Humboldt University, Berlin, Germany. hellmuth.obrig@charite.de

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|December 25, 2002
PubMed
Summary

Near-infrared spectroscopy (NIRS) enables noninvasive brain imaging, mapping cortical oxygenation changes. This technique is valuable for studying neurovascular coupling and diseased brains at the bedside.

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Area of Science:

  • Neuroscience
  • Biomedical Optics
  • Medical Imaging

Background:

  • Optical methods have been used invasively to study cerebral function and metabolism.
  • Near-infrared spectroscopy (NIRS) has evolved for noninvasive functional brain imaging.

Purpose of the Study:

  • To review the extension of optical methods to noninvasive human brain investigation using NIRS imaging.
  • To critically discuss the strengths and weaknesses of NIRS imaging.

Main Methods:

  • Review of intrinsic optical signals and NIRS imaging literature.
  • Focus on noninvasive application of optical methods in humans.

Main Results:

  • NIRS imaging generates maps of cortical oxygenation changes with lower spatial resolution than invasive methods.

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  • NIRS is easily combined with other methods like EEG and is suitable for bedside use.

    • Conclusions:

    • NIRS imaging offers significant advantages for studying neurovascular coupling in adults.
    • NIRS imaging extends functional brain imaging to investigate diseased brains.